ABSTRACT
Introduction: Chinese Sinopharm-CoronaVac® vaccine is safe and well tolerated, its skin reactions are rarely reported. We report the case of a cutaneous adverse reaction due to this vaccine. Observation: A 32-year-old female with no remarkable medical history. She was admitted for a generalized itchy maculo-papular rash appearing 4 days following the administration of the first dose of the Sinopharm-CoronaVac®. The causality reveals a possible association between the vaccine and the drug reaction. Discussion: Published data from randomized trials Phase I and II trials have shown that the Sinopharm-CoronaVac® has good immunogenicity, safety and tolerability in the majority of patients with few reported adverse events. In literature, we found only one case that developed a cutaneous rash due to Sinopharm-CoronaVac® vaccine but without any precisions. Conclusion: We report the first case of a cutaneous adverse reaction type Maculopapular rash after the first dose of the Sinopharm-CoronaVac® vaccine.
ABSTRACT
Preventive measures including mask wearing are crucial in slowing the transmission of COVID-19 disease. However, prolonged wearing of protective masks can easily generate excessive sweating, moisture and friction. Closed and warm environments heighten the skin's permeability and sensitivity to physical or chemical irritants, leading to chronic cumulative irritant contact dermatitis or, rarely, even allergic contact dermatitis. Although not representing a life-threatening condition, allergic contact dermatitis create emotional discomfort due to the involvement of evident body areas. To minimize the skin breakdown, adherence to standards on wearing protective and safe equipments and avoidance of overprotection should be performed.